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Article

A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system.

Journal of molecular biology - 28 Mar 2003

Carlson Cathrine R, Ruppelt Anja, Taskén Kjetil

Abstract excerpt

Protein kinase A (PKA) regulatory (R) subunits dimerize through an N-terminal motif. Such dimerization is necessary for binding to PKA anchoring proteins (AKAPs) and targeting of PKA to its site of action. In the present study, we used the yeast two-hybrid system as an in vivo bio-reporter assay and analyzed the formation of homo- and heterodimeric complexes of RIalpha and RIbeta as well as AKAP binding of RI...

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Share to A Kinase Anchor Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP-Dependent Protein Kinase RIalpha Subunit

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Share to Dimerization

Share to Electrophoresis, Polyacrylamide Gel

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Source

Identifiers

PMID: 12634056
DOI: 10.1016/s0022-2836(03)00093-7

Genes

AKAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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