Temperature-programmed capillary electrophoresis for the analysis of high-melting point mutants in thalassemias.

doi:10.1002/elps.1150180511

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Article

Temperature-programmed capillary electrophoresis for the analysis of high-melting point mutants in thalassemias.

Electrophoresis - 1 May 1997

Gelfi C, Righetti P G, Travi M, Fattore S

Abstract excerpt

The behavior of different sieving polymers for unambiguous determination of point mutations in genomic DNA, based on electrophoresis in thin capillaries, is evaluated. High melters from thalassemia patients are separated by exploiting the principle of denaturing gradient gel electrophoresis, in f...

Topics

DNA
DNA Mutational Analysis
Electrophoresis, Capillary
Globins
Humans
Mutation
Nucleic Acid Denaturation
Temperature
beta-Thalassemia

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