Article
The adaptability of Escherichia coli thioredoxin to non-conservative amino acid substitutions.
Protein science : a publication of the Protein Society - 1 Jun 1997
O'Brien R, Wynn R, Driscoll P C, Davis B, Plaxco K W, Sturtevant J M, Ladbury J E
Abstract excerpt
The adaptability of Escherichia coli thioredoxin to the substitution of a series of non-natural amino acids has been investigated. Different thiosulfonated alkyl groups were inserted into the hydrophobic core of the protein in position 78 via disulfide bonding with a buried cysteine residue as previously described (Wynn R, Richards FM. 1993. Unnatural amino acid packing mutants of Escherichia coli thioredoxin...
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