Article
Role of conservative mutations in protein multi-property adaptation.
The Biochemical journal - 15 Jul 2010
Rodriguez-Larrea David, Perez-Jimenez Raul, Sanchez-Romero Inmaculada, Delgado-Delgado Asuncion, Fernandez Julio M, Sanchez-Ruiz Jose M
Abstract excerpt
Protein physicochemical properties must undergo complex changes during evolution, as a response to modifications in the organism environment, the result of the proteins taking up new roles or because of the need to cope with the evolution of molecular interacting partners. Recent work has emphasized the role of stability and stability-function trade-offs in these protein adaptation processes. In the present...
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