Article
Lower antigen site density and weak D immunogenicity cannot be explained by structural genomic abnormalities or regulatory defects of the RHD gene.
Transfusion - 1 Jun 1997
Beckers E A, Faas B H, Ligthart P, Overbeeke M A, von dem Borne A E, van der Schoot C E, van Rhenen D J
Abstract excerpt
BACKGROUND: The weak D phenotype is characterized serologically by a weak or negative agglutination reaction with polyclonal anti-D in an immediate-spin test. Agglutination is enhanced in the indirect antiglobulin test. Red cells that are typed weak D have a much lower number of apparently complete D antigens at their cell surface and are associated with considerably weaker immunogenicity than are red cells with...
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