Article
Molecular basis of the altered antigenic expression of RhD in weak D(Du) and RhC/e in RN phenotypes.
Blood - 1 Jun 1996
Rouillac C, Gane P, Cartron J, Le Pennec P Y, Cartron J P, Colin Y
Abstract excerpt
The RH blood group locus is composed of two sequence-related genes, RHD and RHCE, encoding the D, Cc, and Ee antigens in common Rh-positive phenotypes. In this report, we have analyzed the molecular basis of Rh antigens expression in weak D (Du) and RN donors, in whom there is a severe reduction of the D and C/e antigens, respectively. Genomic and transcript analysis of three unrelated low-grade weak D (Du)...
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