Molecular basis of the altered antigenic expression of RhD in weak D(Du) and RhC/e in RN phenotypes.

Article

Molecular basis of the altered antigenic expression of RhD in weak D(Du) and RhC/e in RN phenotypes.

Blood - 1 Jun 1996

Rouillac C, Gane P, Cartron J, Le Pennec P Y, Cartron J P, Colin Y

Abstract excerpt

The RH blood group locus is composed of two sequence-related genes, RHD and RHCE, encoding the D, Cc, and Ee antigens in common Rh-positive phenotypes. In this report, we have analyzed the molecular basis of Rh antigens expression in weak D (Du) and RN donors, in whom there is a severe reduction...

Topics

Alleles
Base Sequence
Exons
Gene Expression Regulation
Genetic Variation
Humans
Models, Molecular
Molecular Sequence Data
Phenotype
Polymerase Chain Reaction
Recombination, Genetic
Rh-Hr Blood-Group System
Transcription, Genetic

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