Article
Cell-free synthesis and assembly of connexins into functional gap junction membrane channels.
The EMBO journal - 15 May 1997
Falk M M, Buehler L K, Kumar N M, Gilula N B
Abstract excerpt
Several different gap junction channel subunit isotypes, known as connexins, were synthesized in a cell-free translation system supplemented with microsomal membranes to study the mechanisms involved in gap junction channel assembly. Previous results indicated that the connexins were synthesized...
Topics
- Cell-Free System
- Connexins
- Gap Junctions
- Ion Channels
- Lipid Bilayers
- Membrane Fusion
- Microsomes
- Mutation
- Patch-Clamp Techniques
- Protein Binding
- Protein Biosynthesis
- Protein Processing, Post-Translational
- Sequence Deletion