Article
Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum.
The Journal of biological chemistry - 3 Jun 2005
Maza Jose, Das Sarma Jayasri, Koval Michael
Abstract excerpt
In contrast to most multimeric transmembrane complexes that oligomerize in the endoplasmic reticulum (ER), the gap junction protein connexin43 (Cx43) oligomerizes in an aspect of the Golgi apparatus. The mechanisms that prevent oligomerization of Cx43 and related connexins in the ER are not well understood. Also, some studies suggest that connexins can oligomerize in the ER. We used connexin constructs containing...
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