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Article

The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition.

The Journal of cell biology - 16 Jun 1997

Savagner P, Yamada K M, Thiery J P

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is an essential morphogenetic process during embryonic development. It can be induced in vitro by hepatocyte growth factor/scatter factor (HGF/SF), or by FGF-1 in our NBT-II cell model for EMT. We tested for a central role in EMT of a zinc-finger protein called Slug. Slug mRNA and protein levels were increased transiently in FGF-1-treated NBT-II cells. Transient or stable...

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Identifiers

PMID: 9182671
DOI: 10.1083/jcb.137.6.1403
PMCID: PMC2132541

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 11 closest

The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition.PMID 9182671Read ↗

Transcriptional activation of ZEB1 by Slug leads to cooperative regulation of the epithelial-mesenchymal transition-like phenotype in melanoma.Semantic proximity Read ↗

DSG3 facilitates cancer cell growth and invasion through the DSG3-plakoglobin-TCF/LEF-Myc/cyclin D1/MMP signaling pathway.Semantic proximity Read ↗

SLUG in cancer development.Semantic proximity Read ↗

The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cellsSemantic proximity Read ↗

Slug is upregulated during wound healing and regulates cellular phenotypes in corneal epithelial cells.Semantic proximity Read ↗

Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress.Semantic proximity Read ↗

Slug Is Required for Cell Survival during Partial Epithelial-Mesenchymal Transition of HGF-induced TubulogenesisSemantic proximity Read ↗

Angiogenic sprouting is regulated by endothelial cell expression of Slug (Snai2)Semantic proximity Read ↗

Loss of cell surface syndecan-1 causes epithelia to transform into anchorage-independent mesenchyme-like cells.Semantic proximity Read ↗

E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells.Semantic proximity Read ↗

Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration.Semantic proximity Read ↗

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