Article
Effects on mRNA degradation by Escherichia coli transcription termination factor Rho and pBR322 copy number control protein Rop.
Journal of molecular biology - 16 May 1997
Sozhamannan S, Stitt B L
Abstract excerpt
Mutants in Escherichia coli transcription termination factor Rho, termed rho(nusD), were previously isolated based on their ability to block the growth of bacteriophage T4. Here we show that rho(nusD) strains have decreased average half-lives for bulk cellular mRNA. Decreased E. coli message lifetimes could be because of increased ribonuclease activity in the rho mutant cells: if a Rho-dependent terminator...
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