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Article

Mechanism of Fas signaling regulation by human herpesvirus 8 K1 oncoprotein.

Journal of the National Cancer Institute - 18 Mar 2009

Berkova Zuzana, Wang Shu, Wise Jillian F, Maeng Hoyoung, Ji Yuan, Samaniego Felipe

Abstract excerpt

BACKGROUND: Herpesvirus 8 (HHV-8) oncoprotein K1 is linked to lymphoproliferation and suppression of apoptosis mediated by the Fas death receptor. Expression of K1 in transgenic mice induces accumulation of lymphoid tissue cells and lymphoma. METHODS: To examine how K1 and Fas interact to suppress apoptosis, K1-Fas binding was studied in human embryonic kidney (HEK) and lymphoma (BJAB) cells that expressed...

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Identifiers

PMID: 19276446
DOI: 10.1093/jnci/djn516
PMCID: PMC2720696

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