Article
HLA-DR4 influences glial activity in Alzheimer's disease hippocampus.
Journal of the neurological sciences - 26 Nov 1998
Aisen P S, Luddy A, Durner M, Reinhard J F, Pasinetti G M
Abstract excerpt
The importance of inflammatory/immune mechanisms in Alzheimer's disease is supported by evidence that the human leukocyte antigen (HLA)-DR genotype influences risk of the disease, with a protective effect associated with the HLA-DR4 allele. We investigated the influence of the HLA-DR4 allele on glial activity, assessed by quantification of glial fibrillary acidic protein (GFAP), in hippocampal tissue from...
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