Article
A role for phosphorylation by casein kinase II in modulating Antennapedia activity in Drosophila.
Genes & development - 15 May 1997
Jaffe L, Ryoo H D, Mann R S
Abstract excerpt
We present evidence that the in vivo activity of the HOX protein Antennapedia (ANTP) is modified because of phosphorylation by the serine/threonine kinase casein kinase II (CKII). Using an in vivo assay a form of ANTP that has alanine substitutions at its CKII target sites has, in addition to wild-type ANTP functions, the ability to alter severely thoracic and abdominal development. The novel functions of this...
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