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Article

Antiviral activity of shiga toxin requires enzymatic activity and is associated with increased permeability of the target cells.

Infection and immunity - 1 Jan 2003

Basu Indira, Ferens Witold A, Stone Diana M, Hovde Carolyn J

Abstract excerpt

This study expanded our earlier finding that Shiga toxin type 1 (Stx1) has activity against bovine leukemia virus (BLV) (W. A. Ferens and C. J. Hovde, Infect. Immun. 68:4462-4469, 2000). The Stx molecular motifs required for antiviral activity were identified, and a mechanism of Stx action on virally infected cells is suggested. Using inhibition of BLV-dependent spontaneous lymphocyte proliferation as a measure...

Topics

Animals
Antiviral Agents
B-Lymphocytes
Cattle
Cattle Diseases
Cell Membrane Permeability
Enzootic Bovine Leukosis
Glycoside Hydrolases
Leukemia Virus, Bovine
Lymphocyte Activation
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Shiga Toxin 1

Shiga Toxin 2

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Identifiers

PMID: 12496182
DOI: 10.1128/IAI.71.1.327-334.2003
PMCID: PMC143405

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