Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a polymorphism in the transmembrane domain of the protooncogene c-kit in healthy subjects.

Experimental and clinical immunogenetics - 1 Jan 1996

Nagata H, Worobec A S, Metcalfe D D

Abstract excerpt

c-Kit is the receptor for stem cell factor (SCF) and is found on hematopoietic stem cells, mast cells, melanocytes, and germ cells. Aggregation of c-Kit by SCF regulates cell proliferation, differentiation, and survival. In the process of examining c-Kit, a polymorphism in the transmembrane domain of the protooncogene c-Kit was identified. This polymorphism consisted of an A-to-C transversion at nucleotide (nt)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Exons
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heterozygote

Share to Homozygote

Share to Membrane Proteins

Share to Point Mutation

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 9165275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a polymorphism in the transmembrane domain of the protooncogene c-kit in healthy subjects.PMID 9165275Read ↗

Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder.Semantic proximity Read ↗

Association of paediatric mastocytosis with a polymorphism resulting in an amino acid substitution (M541L) in the transmembrane domain of c-KITSemantic proximity Read ↗

KIT exon 10 variant (c.1621 A > C) single nucleotide polymorphism as predictor of GIST patient outcome.Semantic proximity Read ↗

Novel R634W c-kit mutation identified in familial mastocytosis.Semantic proximity Read ↗

Identification and in silico analysis of noval alteration Arg420Gly in KIT proto oncogene among acute myeloid leukemia patients.Semantic proximity Read ↗

Lack of<i>c-kit</i>mutation in familial urticaria pigmentosaSemantic proximity Read ↗

Hyperhomocysteinemia due to methionine synthase deficiency, cblG: structure of the MTR gene, genotype diversity, and recognition of a common mutation, P1173L.Semantic proximity Read ↗

Identification of the M541L sequence variation of the transmembrane KIT domain in Merkel cell carcinoma.Semantic proximity Read ↗

Detection of the germline KIT S476I mutation in a kindred with familial mastocytosis associated with gastrointestinal stromal tumors.Semantic proximity Read ↗

Polymerase chain reaction detection of a novel human KIT (mast/stem cell growth factor receptor) gene polymorphism by single-strand conformation polymorphism analysis or by SmaI or BstNI cleavage.Semantic proximity Read ↗

A study of mutations in the c-kit gene of 32 dogs with mastocytoma.Semantic proximity Read ↗

Activating mutations of the c-kit proto-oncogene in a human mast cell leukemia cell line.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.