Identification of a polymorphism in the transmembrane domain of the protooncogene c-kit in healthy subjects.

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Article

Identification of a polymorphism in the transmembrane domain of the protooncogene c-kit in healthy subjects.

Experimental and clinical immunogenetics - 1 Jan 1996

Nagata H, Worobec A S, Metcalfe D D

Abstract excerpt

c-Kit is the receptor for stem cell factor (SCF) and is found on hematopoietic stem cells, mast cells, melanocytes, and germ cells. Aggregation of c-Kit by SCF regulates cell proliferation, differentiation, and survival. In the process of examining c-Kit, a polymorphism in the transmembrane domai...

Topics

Adult
Alleles
Exons
Family Health
Female
Gene Frequency
Heterozygote
Homozygote
Humans
Leucine
Male
Membrane Proteins
Methionine
Middle Aged
Point Mutation
Polymorphism, Genetic
Polymorphism, Single-Stranded Conformational
Protein Structure, Tertiary

Source

Open in PubMed

Identifiers

PMID: 9165275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9165275-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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