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Article

Activating mutations of the c-kit proto-oncogene in a human mast cell leukemia cell line.

Leukemia - 1 Apr 1994

Kanakura Y, Furitsu T, Tsujimura T, Butterfield J H, Ashman L K, Ikeda H, Kitayama H, Kanayama Y, Matsuzawa Y, Kitamura Y

Abstract excerpt

The c-kit proto-oncogene encodes a receptor tyrosine kinase that is known to play a crucial role in mast cell growth and differentiation. In a human mast cell leukemia cell line (HMC-1), KitR was found to be constitutively phosphorylated on tyrosine, activated and associated with phosphatidylinos...

Topics

Humans
Leukemia, Mast-Cell
Mutation
Proto-Oncogene Mas
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-kit
Proto-Oncogenes
Receptor Protein-Tyrosine Kinases
Receptors, Colony-Stimulating Factor
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7512180

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7512180-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Activating mutations of the c-kit proto-oncogene in a human mast cell leukemia cell line.PMID 7512180Read ↗

Functional and phenotypic studies of two variants of a human mast cell line with a distinct set of mutations in the c-kit proto-oncogene.Semantic proximity Read ↗

Substitution of an aspartic acid results in constitutive activation of c-kit receptor tyrosine kinase in a rat tumor mast cell line RBL-2H3.Semantic proximity Read ↗

C-kit mutations and mast cell disorders. A model of activating mutations of growth factor receptors.Semantic proximity Read ↗

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Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder.Semantic proximity Read ↗

Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412.Semantic proximity Read ↗

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A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumors.Semantic proximity Read ↗

[Therapeutically relevant mutations in the receptor tyrosine kinase KIT in mastocytosis].Semantic proximity Read ↗

The c-Kit/D816V mutation eliminates the differences in signal transduction and biological responses between two isoforms of c-Kit.Semantic proximity Read ↗

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