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Article

Identification of the M541L sequence variation of the transmembrane KIT domain in Merkel cell carcinoma.

Anticancer research - 1 Mar 2011

Krasagakis Konstantin, Metaxari Maria, Zervou Maria, Stathopoulos Eustathios N, Eberle Juergen, Kanitakis Jean, Georgoulias Vassilis, Krüger-Krasagakis Sabine, Tavernarakis Nektarios, Tosca Androniki D

Abstract excerpt

BACKGROUND: Merkel cell carcinoma (MCC) is an aggressive KIT-positive cutaneous tumor. KIT mutations are considered to play a key role in the pathogenesis of various neoplasms, but have not been found so far in MCC. The aim of the present study was therefore to investigate the presence of KIT mutations in MCC. MATERIALS AND METHODS: The entire coding region of KIT in the MCC cell line MCC-1 was sequenced. KIT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-kit

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Source

Identifiers

PMID: 21498700

Genes

KIT
MCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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