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Article

KIT exon 10 variant (c.1621 A > C) single nucleotide polymorphism as predictor of GIST patient outcome.

BMC cancer - 24 Oct 2015

Brahmi Mehdi, Alberti Laurent, Dufresne Armelle, Ray-Coquard Isabelle, Cassier Philippe, Meeus Pierre, Decouvelaere Anne-Valérie, Ranchère-Vince Dominique, Blay Jean-Yves

Abstract excerpt

BACKGROUND: Tumor genotype plays a crucial role in clinical management of GIST. Whether genetic polymorphism of KIT may influence GIST patient outcome is unclear. METHODS: We investigated the biological and clinical significance of the presence of KIT exon 10 variant (c.1621 A > C), KIT (L541), in a transfected cell line (3 T3 L541) and in two retrospectively collected series of 109 GIST patients in total. The...

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Identifiers

PMID: 26498480
DOI: 10.1186/s12885-015-1817-5
PMCID: PMC4619434

Genes

KIT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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