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Article

Identification and in silico analysis of noval alteration Arg420Gly in KIT proto oncogene among acute myeloid leukemia patients.

Scientific reports - 10 Nov 2022

Akram Afia Muhammad, Hassan Mubashir, Chaudhary Asma, Hayat Sikandar, Ali Qurban, Hussain Taha, Zafar Amjad, Javed Muhammad Arshad

Abstract excerpt

A number of studies have reported frequent incidence of c-kit gene mutations in association with core binding factor acute myeloid leukemia (CBF-AML). These genetic changes have become important prognostic predictors in patients with abnormal karyotype. Aim of this study was the detection of nucleotide alterations in newly diagnosed acute myeloid leukemia patients for three exons of c-kit gene, including...

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Identifiers

PMID: 36357474
DOI: 10.1038/s41598-022-23934-y
PMCID: PMC9649709

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