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Mesenchymal stem cells preserve their stem cell traits after exposure to antimetabolite chemotherapy

13 Aug 2019

Abstract excerpt

BACKGROUND: Mesenchymal stem cells (MSCs) participate in the regeneration of tissue lesions induced by antimetabolite chemotherapy; however, the influence of this class of anti-cancer compounds on the stem cells remains largely unknown. METHODS: The survival of MSCs after exposure to 5-fluorouracil (5-FU) and gemcitabine was measured by viability and clonogenic assays. MSC morphology, surface marker expression,...

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PMID: 31437767
DOI: 10.1016/j.scr.2019.101536

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