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Article

Relationship of major histocompatibility complex class II genes to inhibitor antibody formation in hemophilia A.

Thrombosis and haemostasis - 28 Dec 1990

Lippert L E, Fisher L M, Schook L B

Abstract excerpt

Approximately 14% of transfused hemophiliacs develop an anti-factor VIII inhibitory antibody which specifically neutralizes factor VIII procoagulant activity. In this study an association of the major histocompatibility complex (MHC) with inhibitor antibody formation was evaluated by restriction fragment length polymorphism (RFLP) analysis using BamHI, EcoRI, HindIII, PstI, PvuII and TaqI digested genomic DNA...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 1982196

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Relationship of major histocompatibility complex class II genes to inhibitor antibody formation in hemophilia A.PMID 1982196Read ↗

Why do inhibitors develop? Principles of and factors influencing the risk for inhibitor development in haemophilia.Semantic proximity Read ↗

A case-control study reveals immunoregulatory gene haplotypes that influence inhibitor risk in severe haemophilia A.Semantic proximity Read ↗

Inhibitor development in hemophiliacs: the roles of genetic versus environmental factors.Semantic proximity Read ↗

Factor VIII inhibitors.Semantic proximity Read ↗

Polymorphisms in the IL10 but not in the IL1beta and IL4 genes are associated with inhibitor development in patients with hemophilia ASemantic proximity Read ↗

The Development of FVIII Inhibitors in Relation to IL10 Gene Polymorphism in Hemophilia A Egyptian Pediatric Patients.Semantic proximity Read ↗

The Malmö International Brother Study (MIBS): further support for genetic predisposition to inhibitor development in hemophilia patients.Semantic proximity Read ↗

Immune regulatory gene polymorphisms as predisposing risk factors for the development of factor VIII inhibitors in Indian severe haemophilia A patients.Semantic proximity Read ↗

HLA class II profile: a weak determinant of factor VIII inhibitor development in severe haemophilia A. UKHCDO Inhibitor Working Party.Semantic proximity Read ↗

Inhibitor development in correlation to factor VIII genotypes.Semantic proximity Read ↗

Risk factors for inhibitor development in hemophilia A.Semantic proximity Read ↗

The polygenic nature of inhibitors in hemophilia A: results from the Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort.Semantic proximity Read ↗

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