Article
Relationship of major histocompatibility complex class II genes to inhibitor antibody formation in hemophilia A.
Thrombosis and haemostasis - 28 Dec 1990
Lippert L E, Fisher L M, Schook L B
Abstract excerpt
Approximately 14% of transfused hemophiliacs develop an anti-factor VIII inhibitory antibody which specifically neutralizes factor VIII procoagulant activity. In this study an association of the major histocompatibility complex (MHC) with inhibitor antibody formation was evaluated by restriction fragment length polymorphism (RFLP) analysis using BamHI, EcoRI, HindIII, PstI, PvuII and TaqI digested genomic DNA...
Topics
- Adsorption
- Antibody Formation
- Factor VIII
- Genes, MHC Class II
- HLA-DQ Antigens
- HLA-DR Antigens
- Hemophilia A
- Humans
- Male
- Phenotype
- Polymorphism, Restriction Fragment Length