Article
Chloride channels and cystic fibrosis of the pancreas.
Bioscience reports - 1 Dec 1995
Gray M A, Winpenny J P, Verdon B, McAlroy H, Argent B E
Abstract excerpt
Cystic fibrosis (CF) affects approximately 1 in 2000 people making it one of the commonest fatal, inherited diseases in the Caucasian population. CF is caused by mutations in a cyclic AMP-regulated chloride channel known as CFTR, which is found on the apical plasma membrane of many exocrine epithelial cells. In the CF pancreas, dysfunction of the CFTR reduces the secretory activity of the tubular duct cells,...
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