Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Islet-intrinsic effects of CFTR mutation.

Diabetologia - 1 Jul 2016

Koivula Fiona N Manderson, McClenaghan Neville H, Harper Alan G S, Kelly Catriona

Abstract excerpt

Cystic fibrosis-related diabetes (CFRD) is the most significant extra-pulmonary comorbidity in cystic fibrosis (CF) patients, and accelerates lung decline. In addition to the traditional view that CFRD is a consequence of fibrotic destruction of the pancreas as a whole, emerging evidence may implicate a role for cystic fibrosis transmembrane-conductance regulator (CFTR) in the regulation of insulin secretion from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CFTR gene
Share to Insulin-Secreting Cells
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystic Fibrosis

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Source

Open in PubMed Open full text

Identifiers

PMID: 27033560
DOI: 10.1007/s00125-016-3936-1
PMCID: PMC4901107

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Islet-intrinsic effects of CFTR mutation.PMID 27033560Read ↗

The Potential Causes of Cystic Fibrosis-Related Diabetes.Semantic proximity Read ↗

Unravelling the developmental origins of cystic fibrosis-related diabetes.Semantic proximity Read ↗

Cystic Fibrosis-Related Diabetes (CFRD): Overview of Associated Genetic FactorsSemantic proximity Read ↗

Update on cystic fibrosis-related diabetes.Semantic proximity Read ↗

Cystic fibrosis-related diabetes is caused by islet loss and inflammation.Semantic proximity Read ↗

Pancreatic complications in children with cystic fibrosis.Semantic proximity Read ↗

Managing diabetes in cystic fibrosis.Semantic proximity Read ↗

Current clinical opinion on CFTR dysfunction and patient risk of pancreatitis: diagnostic and therapeutic considerations.Semantic proximity Read ↗

Pancreatic involvement in cystic fibrosis.Semantic proximity Read ↗

Single cell and spatial characterization of the human pancreas reveals drivers of beta cell dysfunction in cystic fibrosisSemantic proximity Read ↗

Total Pancreatectomy With Intraportal Islet Autotransplantation as a Treatment of Chronic Pancreatitis in Patients With CFTR Mutations.Semantic proximity Read ↗

[Cystic fibrosis diabetes in adult].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.