Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis.

doi:10.1053/j.gastro.2014.11.002

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Article

Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis.

Gastroenterology - 1 Feb 2015

Maléth József, Balázs Anita, Pallagi Petra, Balla Zsolt, Kui Balázs, Katona Máté, Judák Linda, Németh István, Kemény Lajos V, Rakonczay Zoltán, Venglovecz Viktória, Földesi Imre, Pető Zoltán, Somorácz Áron, Borka Katalin, Perdomo Doranda, Lukacs Gergely L, Gray Mike A, Monterisi Stefania, Zaccolo Manuela, Sendler Matthias, Mayerle Julia, Kühn Jens-Peter, Lerch Markus M, Sahin-Tóth Miklós, Hegyi Péter

Abstract excerpt

BACKGROUND & AIMS: Excessive consumption of ethanol is one of the most common causes of acute and chronic pancreatitis. Alterations to the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) also cause pancreatitis. However, little is known about the role of CFTR in the pathogenesis of alcohol-induced pancreatitis. METHODS: We measured CFTR activity based on chloride concentrations in...

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Identifiers

PMID: 25447846
DOI: 10.1053/j.gastro.2014.11.002
PMCID: PMC4353632

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CFTR

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