Cystic Fibrosis and the Pancreas

Abstract excerpt

Cystic fibrosis (CF) is inherited as an autosomal recessive trait due to a mutated gene carried on the long arm of chromosome 7. The protein coded by the CF gene (CFTR) is an apical chloride channel that regulates active chloride transport across epithelial cell membranes. The role of CFTR in pancreatic exocrine secretion is based on the concept that CFTR is localized to the apical membrane of the proximal duct...

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