Article
The cystic fibrosis of exocrine pancreas.
Cold Spring Harbor perspectives in medicine - 1 May 2013
Wilschanski Michael, Novak Ivana
Abstract excerpt
The cystic fibrosis transmembrane conductance regulator (CFTR) protein is highly expressed in the pancreatic duct epithelia and permits anions and water to enter the ductal lumen. This results in an increased volume of alkaline fluid allowing the highly concentrated proteins secreted by the acinar cells to remain in a soluble state. This work will expound on the pathophysiology and pathology caused by the...
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