Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bicarbonate Transport in Cystic Fibrosis and Pancreatitis.

Cells - 24 Dec 2021

Angyal Dora, Bijvelds Marcel J C, Bruno Marco J, Peppelenbosch Maikel P, de Jonge Hugo R

Abstract excerpt

CFTR, the cystic fibrosis (CF) gene-encoded epithelial anion channel, has a prominent role in driving chloride, bicarbonate and fluid secretion in the ductal cells of the exocrine pancreas. Whereas severe mutations in CFTR cause fibrosis of the pancreas in utero, CFTR mutants with residual function, or CFTR variants with a normal chloride but defective bicarbonate permeability (CFTRBD), are associated with an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bicarbonates
Share to Biological Transport
Share to Cystic Fibrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Share to Mutation

Share to Pancreatitis

Source

Open in PubMed Open full text

Identifiers

PMID: 35011616
DOI: 10.3390/cells11010054
PMCID: PMC8750324

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bicarbonate Transport in Cystic Fibrosis and Pancreatitis.PMID 35011616Read ↗

Mechanisms of CFTR functional variants that impair regulated bicarbonate permeation and increase risk for pancreatitis but not for cystic fibrosis.Semantic proximity Read ↗

The cystic fibrosis of exocrine pancreas.Semantic proximity Read ↗

Current clinical opinion on CFTR dysfunction and patient risk of pancreatitis: diagnostic and therapeutic considerations.Semantic proximity Read ↗

Differential Expression and Microsystem Physiology Reveal Predominant and Drug Reversible CFTR-Related Defects in Idiopathic PancreatitisSemantic proximity Read ↗

Impaired pancreatic ductal bicarbonate secretion in cystic fibrosis.Semantic proximity Read ↗

Bicarbonate defective CFTR variants increase risk for chronic pancreatitis: A meta-analysis.Semantic proximity Read ↗

Pancreatic complications in children with cystic fibrosis.Semantic proximity Read ↗

Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis.Semantic proximity Read ↗

The changing face of the exocrine pancreas in cystic fibrosis: pancreatic sufficiency, pancreatitis and genotype.Semantic proximity Read ↗

Cystic fibrosis in the pancreas: recent advances provide new insights.Semantic proximity Read ↗

Genetics of pancreatitis with a focus on the pancreatic ducts.Semantic proximity Read ↗

Pancreatitis and cystic fibrosis gene mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.