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Article

Haemocyte-derived SPARC is required for collagen-IV-dependent stability of basal laminae in <i>Drosophila</i> embryos

29 Apr 2008

Abstract excerpt

SPARC is an evolutionarily conserved collagen-binding extracellular matrix (ECM) glycoprotein whose morphogenetic contribution(s) to embryonic development remain elusive despite decades of research. We have therefore used Drosophila genetics to gain insight into the role of SPARC during embryogenesis. In Drosophila embryos, high levels of SPARC and other basal lamina components (such as network-forming collagen...

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PMID: 18445681
DOI: 10.1242/jcs.021931

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