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Article

Abnormal Schwann cell/axon interactions in the Trembler‐J mouse

1 Apr 1997

Abstract excerpt

The Trembler-J (TrJ) mouse has a point mutation in the gene coding for peripheral myelin protein 22 (PMP22). Disturbances in PMP22 are associated with abnormal myelination in a range of inherited peripheral neuropathies both in mice and humans. PMP22 is produced mainly by Schwann cells in the peripheral nervous system where it is localised to compact myelin. The function of PMP22 is unclear but its low abundance...

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Identifiers

PMID: 9147228
DOI: 10.1046/j.1469-7580.1997.19030423.x

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