Progress in the molecular understanding of hereditary peripheral neuropathies reveals new insights into the biology of the peripheral nervous system.

Abstract excerpt

Since the first description of the autosomal dominant inherited peripheral neuropathy Charcot-Marie-Tooth (CMT) disease over a century ago, there has been considerable disagreement, based on morphological abnormalities of both the axons of peripheral nerves and their surrounding Schwann cells, as to whether this disorder is due primarily to an autonomous Schwann cell defect or an autonomous neuronal defect....

Topics

• Amino Acid Sequence
• Animals
• Axons
• Cell Communication
• Charcot-Marie-Tooth Disease
• Chromosomes, Human, Pair 17
• Hereditary Sensory and Motor Neuropathy
• Humans
• Mice
• Mice, Neurologic Mutants
• Models, Molecular