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Article

Normal nerve striations are altered in the trembler-J mouse, a model of Charcot-Marie-Tooth disease.

Muscle & nerve - 1 Feb 2015

Power Bridget J, O'reilly Gavin, Murphy Robert, Murphy Keith J, Pickering Mark, Jones James F X

Abstract excerpt

INTRODUCTION: This study was initiated because it was noted that the peripheral nerves of Trembler-J mice (a model of human Charcot-Marie-Tooth disease) appear to lack normal striations. METHODS: We performed confocal microscopy of whole sciatic nerves and tested the effect of axial stress on impulse conduction. RESULTS: We found that the axons of mutant mice were longer than those of the wild-type (1.55 mm of...

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Source

Identifiers

PMID: 24890015
DOI: 10.1002/mus.24303

Genes

PMP22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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