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Article

Peripheral myelin protein 22: facts and hypotheses.

Journal of neuroscience research - 1 Feb 1995

Suter U, Snipes G J

Abstract excerpt

Mutations affecting the peripheral myelin protein 22 (PMP22) gene are associated with inherited motor and sensory neuropathies in mouse (Trembler and Trembler-J) and human (Charcot-Marie-Tooth disease type 1A and Dejerine-Sottas syndrome). Although genetic studies have established a critical role of PMP22 in the formation and/or maintenance of myelin in the peripheral nervous system, the biological function of...

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Source

Identifiers

PMID: 7745607
DOI: 10.1002/jnr.490400202

Genes

PMP22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Peripheral myelin protein 22: facts and hypotheses.PMID 7745607Read ↗

Many facets of the peripheral myelin protein PMP22 in myelination and disease.Semantic proximity Read ↗

The PMP22 gene and its related diseases.Semantic proximity Read ↗

Clinical implications of peripheral myelin protein 22 for nerve compression and neural regeneration: a review.Semantic proximity Read ↗

Identification of the regulatory region of the peripheral myelin protein 22 (PMP22) gene that directs temporal and spatial expression in development and regeneration of peripheral nerves.Semantic proximity Read ↗

Molecular anatomy and genetics of myelin proteins in the peripheral nervous system.Semantic proximity Read ↗

Peripheral myelin protein 22 alters membrane architecture.Semantic proximity Read ↗

Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.Semantic proximity Read ↗

Roles for PMP22 in Schwann cell cholesterol homeostasis in health and disease.Semantic proximity Read ↗

Peripheral myelin protein 22 is a constituent of intercellular junctions in epithelia.Semantic proximity Read ↗

Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice.Semantic proximity Read ↗

Trembler mouse carries a point mutation in a myelin gene.Semantic proximity Read ↗

Molecular pathogenesis of peripheral neuropathy.Semantic proximity Read ↗

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