Article
Major effects on teratogen-induced facial clefting in mice determined by a single genetic region.
Genetics - 1 Sept 1990
Karolyi J, Erickson R P, Liu S, Killewald L
Abstract excerpt
A major correlation has been found between the incidence of glucocorticoid-induced cleft palate and the chromosome 8 segment identified by N-acetyl transferase in mice. The resistant strain became fully susceptible while the susceptible strain became resistant when this chromosomal region, representing less than 0.7% of the genome, was transferred from one strain to the other by the construction of congenic...
Topics
- 6-Aminonicotinamide
- Abnormalities, Drug-Induced
- Animals
- Chromosomes
- Cleft Lip
- Cleft Palate
- Genes
- Mice
- Mice, Inbred C57BL
- Phenotype
- Phenytoin
- Teratogens