Article
Angiotensinogen (M235T) and angiotensin-converting enzyme (I/D) polymorphisms in association with plasma renin and prorenin levels.
Journal of hypertension - 1 Dec 1998
Danser A H, Derkx F H, Hense H W, Jeunemaître X, Riegger G A, Schunkert H
Abstract excerpt
OBJECTIVE: The angiotensinogen T235 allele is associated with elevated plasma angiotensinogen levels whereas the angiotensin-converting enzyme (ACE) deletion (D) allele is associated with elevated ACE activity. It remains unclear, however, whether these genetically mediated elevations of angiotensinogen and ACE levels are functionally relevant Given that the renin-angiotensin system is subject to renin feedback...
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