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Article

Formation of a functional hepatitis B virus replication initiation complex involves a major structural alteration in the RNA template.

Molecular and cellular biology - 1 Nov 1998

Beck J, Nassal M

Abstract excerpt

The DNA genome of a hepatitis B virus is generated by reverse transcription of the RNA pregenome. Replication initiation does not involve a nucleic acid primer; instead, the hepadnavirus P protein binds to the structured RNA encapsidation signal epsilon, from which it copies a short DNA primer that becomes covalently linked to the enzyme. Using in vitro-translated duck hepatitis B virus (DHBV) P protein, we...

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Identifiers

PMID: 9774643
DOI: 10.1128/MCB.18.11.6265
PMCID: PMC109213

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Source receipt: pubmed, retrieved 7 Sept 2026.

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