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Article

An abnormal ketamine response in mutants defective in the ryanodine receptor gene ryr-1 (unc-68) of Caenorhabditis elegans.

Journal of molecular biology - 11 Apr 1997

Sakube Y, Ando H, Kagawa H

Abstract excerpt

To characterize excitation-contraction coupling in Caenorhabditis elegans, we applied two approaches. First, we isolated a mutant having abnormal responses to ketamine, an anesthetic in vertebrates. The novel mutation unc-68(kh30) (isolated as kra-1(kh30)), exhibited strict ketamine-dependent convulsions followed by paralysis. Second, we cloned the C. elegans ryanodine receptor gene ryr-1 that is located near the...

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Identifiers

PMID: 9135117
DOI: 10.1006/jmbi.1997.0910

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