An abnormal ketamine response in mutants defective in the ryanodine receptor gene ryr-1 (unc-68) of Caenorhabditis elegans.

doi:10.1006/jmbi.1997.0910

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Article

An abnormal ketamine response in mutants defective in the ryanodine receptor gene ryr-1 (unc-68) of Caenorhabditis elegans.

Journal of molecular biology - 11 Apr 1997

Sakube Y, Ando H, Kagawa H

Abstract excerpt

To characterize excitation-contraction coupling in Caenorhabditis elegans, we applied two approaches. First, we isolated a mutant having abnormal responses to ketamine, an anesthetic in vertebrates. The novel mutation unc-68(kh30) (isolated as kra-1(kh30)), exhibited strict ketamine-dependent con...

Topics

Amino Acid Sequence
Anesthetics, Dissociative
Animals
Animals, Genetically Modified
Aspartic Acid
Caenorhabditis elegans
Calcium Channels
Cloning, Molecular
Gene Expression
Genes, Helminth
Ketamine
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle Contraction

Muscle Proteins

Mutation

N-Methylaspartate

Organ Specificity

Phosphorylation

Source

Open in PubMed

Identifiers

PMID: 9135117
DOI: 10.1006/jmbi.1997.0910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9135117-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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