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Article

An optogenetic arrhythmia model to study catecholaminergic polymorphic ventricular tachycardia mutations.

Scientific reports - 13 Dec 2017

Fischer Elisabeth, Gottschalk Alexander, Schüler Christina

Abstract excerpt

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a condition of abnormal heart rhythm (arrhythmia), induced by physical activity or stress. Mutations in ryanodine receptor 2 (RyR2), a Ca2+ release channel located in the sarcoplasmic reticulum (SR), or calsequestrin 2 (CASQ2), a SR Ca2+ binding protein, are linked to CPVT. For specific drug development and to study distinct arrhythmias, simple...

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Source

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Identifiers

PMID: 29235522
DOI: 10.1038/s41598-017-17819-8
PMCID: PMC5727474

Genes

CASQ2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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