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Article

Sex influences on the penetrance of HLA shared-epitope genotypes for rheumatoid arthritis.

American journal of human genetics - 1 Feb 1996

Meyer J M, Han J, Singh R, Moxley G

Abstract excerpt

The association between rheumatoid arthritis (RA) and HLA DRB1 alleles may arise through linkage disequilibrium with a disease locus or the direct involvement of HLA alleles in RA. In support of the latter possibility, the shared-epitope hypothesis has been postulated, stating that conformationally similar DR beta chains encoded by several DRB1 alleles confer disease susceptibility. To examine these alternative...

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Identifiers

PMID: 8571964
PMCID: PMC1914550

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Sex influences on the penetrance of HLA shared-epitope genotypes for rheumatoid arthritis.PMID 8571964Read ↗

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