Article
Replacement of graft-resident donor-type antigen presenting cells alters the tempo and pathogenesis of murine cardiac allograft rejection.
Transplantation - 15 Aug 2000
Krasinskas A M, Eiref S D, McLean A D, Kreisel D, Gelman A E, Popma S H, Moore J S, Rosengard B R
Abstract excerpt
BACKGROUND: Graft-resident antigen presenting cells (APCs) are potent stimulators of the alloresponse. To test whether replacement of graft-resident donor-type APCs with those of recipient-type alters allorecognition and the pathogenesis of both acute and chronic rejection, we created chimeric hearts for transplantation into naive recipients. METHODS: To replace donor-type APCs with those of recipient-type,...
Topics
- Acute Disease
- Animals
- Antigen-Presenting Cells
- Base Sequence
- Bone Marrow Transplantation
- Chimera
- Chronic Disease
- DNA Primers
- Graft Rejection
- Heart Transplantation
- Histocompatibility Antigens Class II
- Male
- Mice