Article
Evidence that the continued presence of the organ graft and not peripheral donor microchimerism is essential for maintenance of tolerance to alloantigen in vivo in anti-CD4 treated recipients.
Transplantation - 27 Sept 1996
Hamano K, Rawsthorne M A, Bushell A R, Morris P J, Wood K J
Abstract excerpt
The source of donor alloantigen required to maintain tolerance in vivo was evaluated in anti-Cd4 monoclonal antibody (mAb) treated mice. Treatment with a depleting anti-Cd4 mAb at the time of transplantation (day -1,0) induces tolerance to C57BL/10 (H2b) vascularized cardiac allografts in C3H.He...
Topics
- Alleles
- Animals
- Antibodies, Monoclonal
- CD4 Antigens
- CD4-Positive T-Lymphocytes
- Cell Movement
- Chimera
- Graft Survival
- H-2 Antigens
- Heart Transplantation
- Immune Tolerance
- Isoantigens
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Myocardium