Article
Effects of initial tolerance on acquired tolerance to alcohol in two selectively bred rat strains.
Drug and alcohol dependence - 1 Jan 2000
Riley E P, Lochry E A
Abstract excerpt
The extent to which initial sensitivity to alcohol influences acquired tolerance was investigated in two selectively bred rat lines. These two lines have been selectively bred for differences in initial sensitivity to alcohol. The most affected (MA) line shows about a 90% reduction in motor activity following a 1.5 g/kg dose of alcohol compared with only a 40% reduction in least affected (LA) animals. In an...
Topics
- Animals
- Drug Tolerance
- Ethanol
- Genotype
- Motor Activity
- Rats
- Reflex
- Selection, Genetic
- Sleep
- Time Factors