Article
Linkage studies suggest a possible locus for bipolar disorder near the velo-cardio-facial syndrome region on chromosome 22.
American journal of medical genetics - 18 Apr 1997
Lachman H M, Kelsoe J R, Remick R A, Sadovnick A D, Rapaport M H, Lin M, Pazur B A, Roe A M, Saito T, Papolos D F
Abstract excerpt
Velo-cardio-facial syndrome (VCFS) is a congenital anomaly characterized by multiple dysmorphisms, cleft palate, cardiac anomalies, and learning disabilities, that results from a microdeletion of chromosome 22q11. An increased prevalence of psychiatric illness has been observed, with both schizophrenia and bipolar disorder commonly being diagnosed. For these reasons, the VCFS region is an interesting candidate...
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