Article
Chromosome 22q11 deletions, velo-cardio-facial syndrome and early-onset psychosis. Molecular genetic study.
The British journal of psychiatry : the journal of mental science - 1 Nov 2003
Ivanov D, Kirov G, Norton N, Williams H J, Williams N M, Nikolov I, Tzwetkova R, Stambolova S M, Murphy K C, Toncheva D, Thapar A, O'Donovan M C, Owen M J
Abstract excerpt
BACKGROUND: Velo-cardio-facial syndrome (VCFS) is associated with interstitial deletions of chromosome 22q11. About 30% of patients with VCFS have psychosis, and the rate of these deletions in schizophrenia has been reported to be about 1%. Even higher rates of VCFS deletions have been reported for childhood-onset schizophrenia. AIMS: To test the hypothesis that there is an increased rate of VCFS among patients...
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