Article
Ongoing immunoglobulin gene mutations in mantle cell lymphomas.
British journal of haematology - 1 Jan 1997
Du M Q, Diss T C, Xu C F, Wotherspoon A C, Isaacson P G, Pan L X
Abstract excerpt
Mantle cell lymphomas (MCL) frequently show a vaguely follicular growth pattern. This phenomenon is thought to result from the colonization of reactive B-cell follicles by tumour cells. In view of the unique property of the germinal centre environment, antigen stimulation may play a role in the expansion of the tumour. To assess this, we have examined ongoing Ig mutations, which are genetic markers of B cells in...
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