Article
The amdA regulatory gene of Aspergillus nidulans: characterization of gain-of-function mutations and identification of binding sites for the gene product.
Fungal genetics and biology : FG & B - 1 Feb 1997
Andrianopoulos A, Brons J, Davis M A, Hynes M J
Abstract excerpt
Genetic evidence suggests that the amdA gene of Aspergillus nidulans encodes a protein which controls the expression of the amdS and aciA structural genes. The amd166 and amd1666 mutations in the 5' regulatory region of amdS lead to higher levels of amdA-dependent amdS expression. We show here th...
Topics
- Amidohydrolases
- Aspergillus nidulans
- Base Sequence
- Cloning, Molecular
- DNA, Fungal
- DNA-Binding Proteins
- Formate Dehydrogenases
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Genes, Regulator
- Molecular Sequence Data
- Mutation
- Polymorphism, Single-Stranded Conformational
- Promoter Regions, Genetic
- Recombinant Fusion Proteins
- Trans-Activators
- Transcriptional Activation