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Article

FacB, the Aspergillus nidulans activator of acetate utilization genes, binds dissimilar DNA sequences.

The EMBO journal - 1 Apr 1998

Todd R B, Andrianopoulos A, Davis M A, Hynes M J

Abstract excerpt

The facB gene is required for acetate induction of acetamidase (amdS) and the acetate utilization enzymes acetyl-CoA synthase (facA), isocitrate lyase (acuD) and malate synthase (acuE) in Aspergillus nidulans. The facB gene encodes a transcriptional activator with a GAL4-type Zn(II)2Cys6 zinc binuclear cluster DNA-binding domain which is shown to be required for DNA binding. In vitro DNA-binding sites for FacB in...

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Identifiers

PMID: 9524126
DOI: 10.1093/emboj/17.7.2042
PMCID: PMC1170549

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