Article
A mutation affecting amdS expression in Aspergillus nidulans contains a triplication of a cis-acting regulatory sequence.
Molecular & general genetics : MGG - 1 Feb 1990
Katz M E, Saleeba J A, Sapats S I, Hynes M J
Abstract excerpt
In Aspergillus nidulans expression of the acetamidase structural gene, amdS, is under the control of at least four regulatory genes including the trans-acting amdA regulatory gene. A cis-acting mutation (amdI66) consisting of an 18 bp duplication in the 5' region of the amdS gene results in very high levels of acetamidase activity but only in strains carrying semi-dominant mutations in the amdA gene. In selecting...
Topics
- Amidohydrolases
- Aspergillus nidulans
- Base Sequence
- Blotting, Southern
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Genes, Regulator
- Molecular Sequence Data
- Mutation
- Regulatory Sequences, Nucleic Acid