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Article

Analysis of cyclin-dependent kinase inhibitor expression and methylation patterns in human prostate cancers

15 May 2000

Abstract excerpt

BACKGROUND: Downregulation of genes which negatively control cell cycle progression represents a possible mechanism for prostate tumorigenesis. We examined the expression levels of the p16, p15, p14, and retinoblastoma-susceptibility (RB) genes in primary prostate cancers and human prostate cancer cell lines, and correlated this with the DNA methylation levels of two loci in p16. METHODS: The mRNA levels of p16,...

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PMID: 10797499
DOI: 10.1002/(sici)1097-0045(20000515)43:3<233::aid-pros10>3.0.co;2-s

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