Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apolipoprotein E-4 gene dose in clinically diagnosed Alzheimer's disease: prevalence, plasma cholesterol levels and cerebrovascular change.

European archives of psychiatry and clinical neuroscience - 1 Jan 1994

Czech C, Förstl H, Hentschel F, Mönning U, Besthorn C, Geiger-Kabisch C, Sattel H, Masters C, Beyreuther K

Abstract excerpt

The prevalence of the apolipoprotein E-4 allele (ApoE-4) was significantly higher in a referral population of 40 patients with clinically diagnosed Alzheimer's disease than in a sample of non-demented elderly controls (P < 0.01). The highest plasma cholesterol levels were found in demented patien...

Topics

Aged
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Brain
Cerebral Infarction
Cholesterol
Chromosomes, Human, Pair 19
Female
Genetic Carrier Screening

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Humans

Male

Middle Aged

Risk Factors

Source

Identifiers

PMID: 8172944
DOI: 10.1007/BF02191587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8172944-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Apolipoprotein E-4 gene dose in clinically diagnosed Alzheimer's disease: prevalence, plasma cholesterol levels and cerebrovascular change.PMID 8172944Read ↗

Studies on the effect of the apolipoprotein E genotype on the lipid profile in Alzheimer's disease.Semantic proximity Read ↗

Serum apolipoprotein E level is not increased in Alzheimer's disease: the Rotterdam study.Semantic proximity Read ↗

Gene dose effect of the APOE-epsilon4 allele on plasma HDL cholesterol level in patients with Alzheimer's disease.Semantic proximity Read ↗

Increased density of senile plaques (SP), but not neurofibrillary tangles (NFT), in non-demented individuals with the apolipoprotein E4 allele: comparison to confirmed Alzheimer's disease patients.Semantic proximity Read ↗

Preferential deposition of amyloid beta protein (Abeta) in the form Abeta40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E E4 allele.Semantic proximity Read ↗

Apolipoprotein-E genotype in normal aging, age-associated memory impairment, Alzheimer's disease and vascular dementia patients.Semantic proximity Read ↗

CLINICAL BENEFITS OF TRAMIPROSATE IN ALZHEIMER’S DISEASE ARE ASSOCIATED WITH HIGHER NUMBER OF APOE4 ALLELES: THE “APOE4 GENE-DOSE EFFECT”Semantic proximity Read ↗

The effect of apolipoprotein E genotype on biochemical markers of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.