Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The extent of amyloid deposition in brain in patients with Down's syndrome does not depend upon the apolipoprotein E genotype.

Neuroscience letters - 18 Aug 1995

Mann D M, Pickering-Brown S M, Siddons M A, Iwatsubo T, Ihara Y, Asami-Odaka A, Suzuki N

Abstract excerpt

The extent of deposition of amyloid beta protein (A beta) was investigated in 20 elderly patients with Down's syndrome, using the end-specific monoclonal antibodies BC05 and BA27 to detect the presence of A beta 42(43) and A beta 40 (respectively), and related to apolipoprotein E (ApoE) genotype. No significant differences in the amount of A beta deposited in the brain, either as A beta 42(43) or A beta 40, were...

Topics

Aged
Alzheimer Disease
Amyloid beta-Protein Precursor
Antibodies, Monoclonal
Apolipoproteins E
Brain
Down Syndrome
Frontal Lobe
Genotype
Humans
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7501233
DOI: 10.1016/0304-3940(95)11860-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7501233-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

The extent of amyloid deposition in brain in patients with Down's syndrome does not depend upon the apolipoprotein E genotype.PMID 7501233Read ↗

Amyloid beta protein deposition in patients with frontotemporal lobar degeneration: relationship to age and apolipoprotein E genotype.Semantic proximity Read ↗

Neuropathological changes in Down's syndrome hippocampal formation. Effect of age and apolipoprotein E genotype.Semantic proximity Read ↗

Plasma levels of amyloid beta 40 and 42 are independent from ApoE genotype and mental retardation in Down syndrome.Semantic proximity Read ↗

Amyloid β protein (Aβ) deposition in chromosome 14–linked Alzheimer's disease: Predominance of Aβ<sub>42(43)</sub>Semantic proximity Read ↗

ApoE2 allele, Down's syndrome, and dementia.Semantic proximity Read ↗

Amyloid beta concentrations in older people with Down syndrome and dementia.Semantic proximity Read ↗

Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome.Semantic proximity Read ↗

Sequence of Deposition of Heterogeneous Amyloid β-Peptides and APO E in Down Syndrome: Implications for Initial Events in Amyloid Plaque FormationSemantic proximity Read ↗

Plasma beta-amyloid and duration of Alzheimer's disease in adults with Down syndrome.Semantic proximity Read ↗

Preferential deposition of amyloid beta protein (Abeta) in the form Abeta40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E E4 allele.Semantic proximity Read ↗

Elevated plasma amyloid beta-peptide 1-42 and onset of dementia in adults with Down syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.